Professor Gendie E Lash established the Laboratory of Uterine Vascular Biology in the Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, China in July 2015. Dr Gendie E Lash is a Guangzhou high-level foreign expert and was awarded Guangzhou Medical Key Talent status in 2016 and National Foreign Expert Program in 2021 and 2023 for her outstanding research contributions. She has published 150 papers which are cited 5451 times, with an H-index of 41. Dr Gendie E Lash graduated from The University of Otago in Dunedin, New Zealand, and worked at the University of Nottingham (UK), Queen's University (Canada) and Newcastle University (UK). Dr Gendie E Lash is a senior editor for Molecular Reproduction and Development, associate editor (China) for Placenta, and deputy editor for Maternal-Fetal Medicine. She is the immediate past editor of Trophoblast Research (supplement to Placenta), and currently serves on the Editorial Boards of Journal of Reproductive Immunology and Frontiers (Reproduction and Immune Tolerance).  She reviews for a wide range of journals and grant funding bodies. Dr Gendie E Lash is well-known in the obstetrics and gynecology field, and has been invited to speak at many national and international academic conferences. Dr Lash’s research focuses on the role of placental and uterine factors in the regulation of trophoblast invasion and spiral artery remodeling, and key maternal adaptations to pregnancy and determining the pathophysiologic mechanism of the pregnancy complications such as preeclampsia, fetal growth restriction and miscarriage, with the ultimate goal to provide a theoretical basis for prevention and treatment of these disease and improve the reproductive wellbeing of women. More recently, members of Dr Lash’s laboratory have also performed several successful studies on ovarian and endometrial cancer. The laboratory is funded by grants from the General Project of National Natural Science Foundation of China, Guangzhou Science and Technology Project and Youth Science Foundation of National Natural Science Foundation of China, etc. In addition, we were funded by Foundation and Application Foundation Yuehui Union Foundation of Guangdong Province in 2022. The laboratory is well funded, and the current team is comprised of senior scientists, post-doctoral fellows, technicians and Masters students. The research group works well together.

International Collaborations：

Professors Mark Kilby and Martin Hewison （University of Birmingham， UK） – Vitamin D and early pregnancy

Dr Annette Meeson （Newcastle University， UK） – Cancer stem cells and angiogenesis

Dr Jane Girling (University of Otago, NZ) - Heavy menstrual bleeding and obesity

 

Representative Research Grants Awarded：

(1) 广东省基础与应用基础研究区域联合基金-重点项目，《易胜博体育app下载》，2022-2025，100万元，负责人为Gendie E Lash，在研；

(2) 国家自然科学基金面上项目，《天博体育》，2018-2022 ，59万，负责人为Gendie E Lash，结题；

(3) 国家自然科学基金面上项目，《天博体育》，2017-2020，57万元，负责人为Gendie E Lash，结题；

(4) 广州市科技厅产学研协同创新重大专项，《天博体育》，2017-2022，200万元，负责人为Gendie E Lash，结题；

(5) 国家自然科学基金委员会青年科学基金项目，《易胜博体育app下载》，2024-2026，30万元，负责人为甘晓文，在研；

(6) 国家自然科学基金委员会青年科学基金项目，项目编号：81702567，HE4通过Smad信号通路对子宫内膜癌细胞周期的调控机制研究，2018-2020，20万，负责人为卢勤声，结题；

(7) 国家自然科学基金委员会青年科学基金项目，《天博体育》，2018-2020，18万，负责人为陈妙娟，结题；

(8) 国家自然科学基金委员会青年科学基金项目，《天博体育》，2017-2019，20万元，负责人为宁粉，结题。

 

Research Awards and Fellowships：

(1) Gendie E Lash入选2016年广州市医学重点人才

(2) Gendie E Lash 入选2021年珠三角自主创新示范区9市和揭阳中德金属生态城外籍高层次人才

(3) Gendie E Lash获得2021年和2023年高端外国专家引进计划个人项目奖

（4）Gendie E Lash获得2023全球前2%科学家称号

 

Selected Recent Representative Publications：

Maternal adaptation to early pregnancy

(1) Long Y, Zeng S, Gao F, Liu F, Zhang Y, Zhou C, Zhu C, Zhao X, Han M, Gan Q, Ye W, Zeng F, Song C, Jiang M, Lash GE, Yang H. SERPINA5 may promote the development of preeclampsia by disruption of the uPA/uPAR pathway. Transl Res. 2023 Jan;251:14-26. doi: 10.1016/j.trsl.2022.06.011. Epub 2022 Jun 15. PMID: 35717024. (IF=10.171)

(2) Liu H, Chen M, Ning F, Ye Y, Lu Q, Lu S, Duan Y, Gan X, Zhao M, Guo K, Lash GE. Extravillous trophoblast cell-derived exosomes induce vascular smooth muscle cell apoptosis via a mechanism associated with miR-143-3p. Mol Hum Reprod. 2023 Jul 31;29(8):gaad026. doi: 10.1093/molehr/gaad026. PMID: 37369038.（IF=4.0）

(3) Hou H, Ning F, Zhang JY, Lu Q, Zhang M, Wu P, Chen M, Lash GE. Angiopoietin 2 stimulates trophoblast invasion via a mechanism associated with JNK signaling. Mol Hum Reprod. 2021 Feb 27;27(3):gaab014. doi: 10.1093/molehr/gaab014. PMID: 33629098. (IF=6.081)

(4) Zhang JY, Wu P, Chen D, Ning F, Lu Q, Qiu X, Hewison M, Tamblyn JA, Kilby MD, Lash GE. Vitamin D Promotes Trophoblast Cell Induced Separation of Vascular Smooth Muscle Cells in Vascular Remodeling via Induction of G-CSF. Front Cell Dev Biol. 2020 Dec 22;8:601043. doi: 10.3389/fcell.2020.601043. PMID: 33415106; PMCID: PMC7783206. (IF=6.081)

(5) Lash GE, Pitman H, Morgan HL, Innes BA, Agwu CN, Bulmer JN. Decidual macrophages: key regulators of vascular remodeling in human pregnancy. J Leukoc Biol. 2016 Aug;100(2):315-25. doi: 10.1189/jlb.1A0815-351R. Epub 2016 Jan 27. PMID: 26819320.（IF=6.011）

Gynecological cancers

(6) Chen M, Pan Y, Liu H, Ning F, Lu Q, Duan Y, Gan X, Lu S, Hou H, Zhang M, Tian Y, Lash GE. Ezrin accelerates breast cancer liver metastasis through promoting furin-like convertase-mediated cleavage of Notch1. Cell Oncol (Dordr). 2022 Dec 29. doi: 10.1007/s13402-022-00761-x. Epub ahead of print. PMID: 36580262. (IF=7.051)

(7) Duan Y, Yu J, Chen M, Lu Q, Ning F, Gan X, Liu H, Ye Y, Lu S, Lash GE. Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM). J Ovarian Res. 2023 Apr 22;16(1):81. doi: 10.1186/s13048-023-01156-8. Erratum in: J Ovarian Res. 2023 May 11;16(1):91. PMID: 37087461; PMCID: PMC10122320.(IF=4.0)

(8) Zhang M, Lu Q, Hou H, Sun D, Chen M, Ning F, Wu P, Wei D, Duan Y, Pan Y, Lash GE. Garcinol inhibits the proliferation of endometrial cancer cells by inducing cell cycle arrest. Oncol Rep. 2021 Feb;45(2):630-640. doi: 10.3892/or.2020.7900. Epub 2020 Dec 15. PMID: 33416149; PMCID: PMC7757109. (IF=5.435)

(9) Shi K, Wang Q, Su Y, Xuan X, Liu Y, Chen W, Qian Y, Lash GE. Identification and functional analyses of differentially expressed metabolites in early stage endometrial carcinoma. Cancer Sci. 2018 Apr;109(4):1032-1043. doi: 10.1111/cas.13532. Epub 2018 Mar 25. PMID: 29436067; PMCID: PMC5891202. (IF=6.518)

Endometrial disorders

(10) Lu Q, Sun D, Shivhare SB, Hou H, Bulmer JN, Innes BA, Hapangama DK, Lash GE. Transforming Growth Factor (TGF) β and Endometrial Vascular Maturation. Front Cell Dev Biol. 2021 Apr 9;9:640065. doi: 10.3389/fcell.2021.640065. PMID: 33898426; PMCID: PMC8063037. (IF=4.518)

(11) Lu Q, Huang Y, Wu J, Guan Y, Du M, Wang F, Liu Z, Zhu Y, Gong G, Hou H, Zhang M, Zhang JY, Ning F, Chen L, Wang L, Lash GE. T-cadherin inhibits invasion and migration of endometrial stromal cells in endometriosis. Hum Reprod. 2020 Jan 1;35(1):145-156. doi: 10.1093/humrep/dez252. PMID: 31886853. (IF=6.353)

(12) Biswas Shivhare S, Bulmer JN, Innes BA, Hapangama DK, Lash GE. Endometrial vascular development in heavy menstrual bleeding: altered spatio-temporal expression of endothelial cell markers and extracellular matrix components. Hum Reprod. 2018 Mar 1;33(3):399-410. doi: 10.1093/humrep/dex378. PMID: 29309596. (IF=6.353)